Vol. 6, Issue 2 | magazine.pharmatutor.org

PharmaTutor

J.Y Manure*, N.S Naikwade

Department of Pharmaceutical Chemistry

Appasaheb Birnale College of Pharmacy,

South Shivaji Nagar Sangli, India

Cancer is a diseases characterized by out-of-control cell growth. There are various types of cancer, and is

classified by the type of cell that is affected. Cancer harms the body when altered cells divide uncontrollably to

form lumps or masses of tissue called tumors. The recent treatments include chemotherapy, radiotherapy and

Surgery. But this treatment accomplished by several side effect like the destruction of bone marrow cell,

alopecia etc. So there is a need for the new drug for treatment of cancer. Plant-derived chemical may act as

anticancer in many studies. The Plant produces secondary metabolites which are being evaluated for the

anticancer activities leading to the development of new drugs. So in this review we have study different plants

which act as anticancer. And this will encourage further scientific study of traditionally used plants.

Keywords: Anticancer, Plants, Secondary metabolite

The cancer disease is characterized continuous

multiplication of cell with the inability to be

controlled or stopped consequently, forming tumors

of malignant cells with the potential to be

metastatic.

Current

treatments

include

chemotherapy, radiotherapy and chemically derived

drugs. Treatments such as chemotherapy can put

patients under a lot of strain and further damage

their health. Therefore, there is a focus on using

alternative treatments and therapies against cancer.

[Ochwang’I DO et al. 2014]

For many years herbal medicines have been used

and are still used in developing countries as the

primary source of medical treatment. Plants have

been used in medicine for their natural different

properties. The plants extracts preparation shows a

potential anticancer effect for the treatment of

different types of cancer. [Sivaraj R et al. 2014]

There is need for new drugs evaluation for the

treatment of cancer from fruits, vegetables, herbs

and spices. Ethnotraditional use of different plant-

derived natural products plays a significant role in

the discovery and development of potential

medicinal agents. [Torres MP et al. 2012]

Grape seeds are a good source of polyphenols, which

showed a potent antioxidant activity. Thus, grape

seed extract (GES) can be used to treat number of

deadly diseases like cancer (skin cancer, colon cancer

& colorectal cancer) and various bacterial infections.

The petroleum ether extracted of Grape seeds

analyzed for the cytotoxicity against skin cancer cell

lines A431 it showed maximum cell lysis at the

concentration of 500 µg/mL. The IC50 value is 480

µg/mL, which indicated that such concentration

could lyse 50% of skin cancer cell lines. The

morphological changes occurs in treated A431 cell

lines when visualized under an inverted light

microscope showed that the detachment of the cells

from the substratum, cell shrinkage, nuclear

condensation and fragmentation. The morphological

changes included the reduction in the size of the

cells and the cells gradually became shrunken with

the appearance of small bodies. Nature and its

differential features occurred in the cancer cells it

clearly defined the cellular morphological

characteristics, which was typical of cell death. The

GSE could be used in ointments and also injected as

injectable in skin cancer patients to treat skin cancer.

[ Mohansrinivasan V et al. 2015]

Tumor cells trigger angiogenesis through over

expression of various angiogenic factors including

vascular endothelial growth factor (VEGF) and

How to cite this article: Manure JY, Naikwade NS; A Review on: Plants as Anticancer; PharmaTutor; 2018; 6(2); 40-49;

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